孕早期睡眠时长与午睡频次对妊娠糖尿病的影响

目的探讨孕早期睡眠时长和午睡频次对妊娠糖尿病(GDM)的影响。方法采用病例对照研究设计,选取2018年4月至2019年5月在安徽省妇幼保健院、吉安市妇幼保健院产检的孕妇作为研究对象。通过问卷调查收集研究对象的睡眠和午睡等信息,GDM的诊断来自孕中期常规口服葡萄糖耐量试验结果。结果共纳入500名研究对象,其中病例组196人,对照组304人。多元Logistic回归分析结果显示,与睡眠时长7～8.9 h/晚相比,睡眠7、9～9.9、≥10 h/晚的孕妇发生GDM的风险均显著上升;与午睡频次≤5 d/周相比,5 d/周的孕妇发生GDM的风险更高。相比孕早期午睡频率≤5 d/周的孕妇,孕早期睡眠时长不足(7 h/晚)对GDM的影响在午睡频率5 d/周的孕妇中更弱,交互作用具有统计学意义(P=0.002)。结论孕早期睡眠时长、午睡频次均与GDM发病相关,且二者在GDM的发生中存在交互作用。     

The coconut pathosystem: weed hosts of nymphs of the American palm Cixiid Haplaxius crudus (Hemiptera: Fulgoroidea)

Lethal yellowing (LY) of coconut palm (Cocos nucifera L., Arecaceae) is a disease of economic importance that is caused by the phytoplasma ‘Candidatus Phytoplasma palmae’ and is transmitted by the planthopper Haplaxius crudus (Van Duzee) (Hemiptera: Cixiidae). This study explores the weeds used by H. crudus nymphs and other Cixiidae in a coconut pathosystem in southern Mexico. Nymphs were collected directly from the root system of each weed by hand or with the help of a vacuum after carefully opening the culm. This study included 11 species of weeds: nine Poaceae [Brachiaria decumbens Stapf, B. humidicola (Rendle) Schweick, B. mutica (Forssk.) Stapf, Digitaria abyssinica (Hochst. Ex A. Rich.) Stapf, Eustachys petraea (Sw.) Desv., Leersia hexandra Sw., Panicum laxum Sw., P. maximum Jacq., Paspalum notatum Flüggé]; one Cyperaceae [Cyperus ligularis L.], and one Portulacaceae: [Portulaca pilosa L.]. Brachiaria mutica, E. petraea, B. humidicola, P. maximum were identified as the principal host species for H. crudus nymphs. Brachiaria decumbens, D. abyssinica, and C. ligularis are new host records for the nymphs of H. crudus. Additionally, it was found that H. crudus may coexist with its cogeners H. skarphion Kramer (Cixiidae) and H. caldwelli Kramer (Cixiidae), on B. mutica. On C. ligularis, H. crudus may coexist with Oecleus snowi Ball (Cixiidae) nymphs. These results suggest that in the coconut pathosystem there is a complex of multitrophic interactions that should be considered in integrated management of LY.     

县域景观特征管理单元划分方法——以武胜县为例

为了解决目前国内景观特征研究多以大尺度为主且以自然条件为基础, 缺少实际管理意义的问题, 尝试从县域层面进行景观特征单元的划分, 并与现有行政管理单元相结合, 提出发展建议。依据武胜县30 m高程、坡度和土地利用数据, 将武胜县域划分为100 m×100 m的栅格网络, 利用 ArcGIS和SPSS进行二阶聚类分析。结果显示, 武胜县可以划分为7类景观特征管理单元, 单元内部自然地理特征相似, 组间差异显著。将武胜县按聚类结果划分为较单一镇域、较单一村域和较复杂村域 3 种不同的管理模式, 并分析较复杂村域的成因, 提出管理策略。最后, 从景观特征保护出发, 对武胜县 7 处建成区提出规划管理建议。     

Haversian bone-mimicking bioceramic scaffolds enhancing MSC-macrophage osteo-imunomodulation

The interaction between immune cells and bone forming cells plays a vital role in maintaining the homeostasis of the skeletal system, and is regulated by the three-dimensional structure of tissues. Whether the construction of biomaterials can activate or reproduce this spatial “cross-talk” between immune cells and bone forming cells in bone natural formation process is a prerequisite for successful fracture healing and bone regeneration. Herein, a bone marrow mesenchymal stem cells (MSCs)/macrophages-laden Haversian bone-mimicking bioceramic scaffold was successfully prepared through the biomimetic design of biomaterials and 3D printing technology. MSCs and macrophages were respectively distributed in the cancellous bone and Haversian canals of the scaffold to simulate the three-dimensional structure regulation of the cell spatial distribution and multiple intercellular interaction in natural bone tissue, and worked in concert to modulate the scaffold material-mediated osteo-immune microenvironment. The in vitro study revealed that the pro-inflammatory response of macrophages was more significantly inhibited when distributed with MSCs in the scaffolds at a cell ratio of 0.5:1 for co-culture, in comparison with multicellular culture at other ratios and unicellular culture. Meanwhile, MSCs exhibited the relatively high osteogenic potential, most likely via the activation of certain key signaling pathways mediated by macrophages-derived paracrine signaling mediators (OSM, BMP-2, and WNT10b). This work not only establishes a bionic platform for the regulation of multicellular osteo-immune response and regeneration but also offers a promising tissue-engineered biomimetic scaffold with improved immunomodulatory function for promoting bone tissue regeneration.     

双自由度磁悬浮式桥梁振动能量采集器数值仿真和优化

提出了一种能利用桥梁振动能量为传感器持续供电的双自由度磁悬浮振动能量采集器(TMEH),该系统的能量采集效率远高于传统单自由度磁悬浮振动能量采集器(SMEH).推导了TMEH系统的运动控制方程和机电耦合方程;建立了TMEH的多目标优化模型,提出了基于NSGA2算法的能量采集器参数优化设计方法;最后将TMEH和SMEH在简谐振动激励和桥梁随机振动激励作用下的响应特性和能量采集效率进行了对比.研究结果表明:1)通过NSGA2算法优化设计,TMEH能获得更宽的采能带宽和更高的输出功率;2)TMEH比SMEH的采能效率有明显提高.在简谐振动激励和桥梁随机振动激励作用下,TMEH的输出功率比SMEH增加了约2倍.     

高陡横坡段桩柱式桥梁双桩基础受力分析

基于高陡横坡段桩柱式桥梁双桩基础承载特性,提出了一种改进有限杆单元计算分析方法.分析了高陡横坡段桩柱式桥梁双桩基础承载机理及受力特性,建立了双桩基础计算分析模型.其次,根据前、后桩与边坡相对位置关系,给出了后桩所受剩余下滑力与前桩所受土压力的比例关系.在传统有限杆单元分析方法基础上,结合陡坡桩受力特征,导得了考虑桩土共同作用与"P-Δ"效应的单元刚度矩阵修正方法,并在此基础上编制了适用于高陡横坡段桩柱式桥梁双桩基础的有限杆单元分析MATLAB计算程序.采用室内模型试验对本文计算方法进行验证,给出了适用于陡坡段桥梁桩基的设计流程图.研究结果表明:本文理论计算值与模型试验实测结果吻合良好,表明本文计算方法正确可行,可为同类工程设计提供参考.     

Lattice Solid/Boltzmann Microscopic Model to Simulate Solid/Fluid Systems-A Tool to Study Creation of Fluid Flow Networks for Viable Deep Geothermal Energy

SUMMARY:Realizing the potential of geothermal energy as a cheap, green, sustainable resource to provide for the planet’s future energy demands that a key geophysical problem be solved first:how to deve...     

城乡结合部道路交叉口多目标信号配时优化模型

随着我国城镇化进程的加快,城乡结合部道路交通问题日益显著。为提高城乡结合部道路交叉口的交通运行效率、环境效益和交通安全,提出信号配时多目标优化方法,综合考虑延误、通行能力、停车次数、车辆尾气排放等因素构建模型,运用遗传算法进行求解。以某典型交叉口为例进行分析,给出改进设计方案并进行交通仿真评价。研究结果表明,通过多目标信号配时优化可以缓解城乡结合部道路交叉口交通拥堵和污染物排放的问题,具有较好的交通信号控制效果。     

融合多元触觉和沉浸式视觉的可移植VR软件框架

多元触觉和沉浸式视觉反馈的时空一致性配准以及现有VR软件框架中硬件设备的接入便捷性问题,制约了医疗、商务、娱乐等不同行业中视触觉融合场景的快速开发。为解决这一难题,提出融合多元触觉和沉浸式视觉的可移植VR软件框架,根据视触觉反馈精度要求的不同设计了双层和三层架构兼顾视觉渲染、触觉渲染、硬件控制的不同需求。实验结果表明该框架具有支持视-触融合同步反馈、硬件平台可移植、图形场景开发简便和交互场景可快速替换等特点,能够满足不同领域的交互应用需求。     

基于Flash交互动画技术的西湖传统文化保护系统

西湖传统文化保护系统属于非物质文化数字保护的范畴.在非物质文化数字化保护的框架下,以西湖传统文化内容为范例,探讨和建立了以Flash开发平台的Action Script 3.0为基础、交互动画形式为主的多维度交互式展示系统,重点解决基于Flash Action Script 3.0语言为基础的内在技术,尝试以模拟触控平台、无缝链接交互结构及自由信息交互操控三大交互结构设计来实现交互现实体验,从而验证了在数字化媒体艺术中Flash交互动画技术传播传统文化的优势和有效性.